One of my students from Canada recently contacted me after the third small press rejected her memoir manuscript. The publisher was seriously interested but, after some thought. changed his mind. The press offered detailed feedback--in itself an encouragement--which she appreciated.
But it's her third rejection after serious interest, and she's losing heart. "It's been seven years in the writing and revising," she wrote me, "and based on feedback the manuscript has definitely improved. But I'm not sure if I should pursue it anymore."